Predicting Antioxidant, Neuroprotective, and Toxicity Activity of Murraya koenigii Essential Oil by in silico and ex vivo against Rotenone-induced Model

Objectives: To study the antioxidant capacity of Murraya koeingii essential oil (MKEO) phytoconstituents Methods: It was determined by using GCMS. The were then exposed to molecular docking studies that targeted dopamine D2 look for neuroprotective effects. highest percentage content constituents selected as ligands and dopamine(6VMS) retrieved from protein data bank, performed Schrodinger software version 2021-4. pharmacokinetic profile associated with components predicted utilizing ADMET lab 2.0 pkCSM which is a graph-based small pk predictor along toxicity properties constituents. activity MKEO also Ex vivo protocol rotenone an inducing agent in mice brain slices. Findings: potentials nearer positive control (Ascorbic acid) proved MKEO. enzymes CAT GSH decreased slices are treated LPO values decreased. levels dopamine, CAT, improved groups supplemented at different concentrations, reduced levels. Novelty: These results reassuring both In silico investigations had greater activities examined Keywords: koeingii; Neuroprotective; Antioxidant; Toxicity; Parkinson’s Disease